Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3).Lycopene is the most common carotenoid in the human body and is one of the most potent … [3][24] Some foods that do not appear red also contain lycopene, e.g., asparagus, which contains about 30 μg of lycopene per 100-g serving[3] (0.3 μg/g) and dried parsley and basil, which contain around 3.5–7.0 μg/g of lycopene. 13: 407-433 (1992). In its natural, all-trans form, the molecule is long and straight, constrained by its system of 11 conjugated double bonds. An acyclic carotene commonly obtained from tomatoes and other red fruits. [14] The discoloration is expected to fade after discontinuing excessive lycopene intake. 49. In animal models of atherosclerosis, lycopene and tomato products decreased plasma total cholesterol, LDL cholesterol and increased high-density lipoprotein cholesterol. 1997;146(8):618-626.9345115. Khachik F, Beecher GR, … There are many benefits of lycopene including lycopene hplc, and is a powerful antioxidant that neutralises free radicals, especially ones derived from oxygen. The median and 99th percentile of dietary lycopene intake have been estimated to be 5.2 and 123 mg/d, respectively. Stability: Heat sensitive - store at -70 C. Combustible. What is Lycopene. Lipids. Owing to the strong color, lycopene is useful as a food coloring (registered as E160d) and is approved for use in the USA,[5] Australia and New Zealand (registered as 160d)[6] and the European Union. [9], Carotenoids like lycopene are found in photosynthetic pigment-protein complexes in plants, photosynthetic bacteria, fungi, and algae. CC(=CCC/C(=C/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(/CCC=C(C)C)\C)\C)\C)/C)/C)/C)C Lycopene is a key intermediate in the biosynthesis of carotenoids, such as beta-carotene, and xanthophylls. Several human epidemiological studies, supplemented by in vivo and in vitro studies, have shown decreased bone loss following the consumption of lycopene/tomato. Lycopene may affect the immune system, the nervous system, sensitivity to sunlight, or drugs used for stomach ailments. However, a diet high in olive oil and rich in lycopene may decrease the risk of coronary heart disease by improving the serum lipid profile compared with a high-carbohydrate, low-fat, lycopene-rich di … A high level of lycopene reduces the level of oxidized components of DNA, it acts as a kind of prevention of cancer of the stomach and prostate. Cited in 4 publications [33][dead link] A 2020 review of randomized control trials found conflicting findings for lycopene improving cardiovascular risk factors. The extraction process is a unit operation used to obtain targeted food components from natural products such as lycopene from tomatoes. J Nutr. Different isomers were shown to have different stabilities due to their molecular energy (highest stability: 5-cis ≥ all-trans ≥ 9-cis ≥ 13-cis > 15-cis > 7-cis > 11-cis: lowest). MF: C40H56, MW: 536.87. Lycopene is currently the most powerful antioxidant which has been measured in food and is thought to play a role in preventing cancer, heart disease, and macular degeneration. Although lycopene from tomatoes has been tested in humans for cardiovascular diseases and prostate cancer, no effect on any disease was found. [8] In human blood, various cis-isomers constitute more than 60% of the total lycopene concentration, but the biological effects of individual isomers have not been investigated. March 26, 2016. Full Text PDF [647K] Abstracts References(38) Cited-By(2) Intake of the antioxidant lycopene has been reported to decrease oxidative stress and have beneficial effects on bone health. C. Lung cancer prevention. Lycopene extraction from tomatoes, as a promising health-promoting functional food ingredient, is drawing increasing attention by the food industry. Lycopene is a lipid-soluble carotenoid that exists in both all-trans and cis-configurations in nature. 48. ↑ Erdman JW Jr, Ford NA, Lindshield BL. Several human epidemiological studies, supplemented by in vivo and in vitro studies, have shown decreased bone loss following the consumption of lycopene/tomato. These Secondary Standards are qualified as Certified Reference Materials. Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. [4] Lycopene dietary supplements (in oil) may be more efficiently absorbed than lycopene from food. LDL was isolated from plasma by ultracentrifugation. The dual wavelength procedure should be used and the density of the material checked if the sample is to be added by volume. Because of its lipophilic nature, lycopene concentrates in low-density and very-low-density lipoprotein fractions of the serum. However, a diet high in olive oil and rich in lycopene may decrease the risk of coronary heart disease by improving the serum lipid profile compared with a high-carbohydrate, low-fat, lycopene-rich di … Stage 1 hypertensive subjects treated but uncontrolled [4] The lycopene content of tomatoes depends on variety and increases as the fruit ripens. Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Lycopene is a compound or a pigment which gives red color to fruits and vegetables such as tomatoes, watermelon, pink grapefruit and guava. [33] The US Food and Drug Administration (FDA), in rejecting manufacturers' requests in 2005 to allow "qualified labeling" for lycopene and the reduction of various cancer risks, provided a conclusion that remains in effect as of 2017[update]: "...no studies provided information about whether lycopene intake may reduce the risk of any of the specific forms of cancer. [3], In humans, the Observed Safe Level for lycopene is 75 mg/day, according to one preliminary study. [13] In this respect, skin lycopene has been reported to be more sensitive to UV light stress than b-carotene. Density functional theory has been applied to optimize the configurations of the ground and excited states of lycopene and oxygen respectively. Lycopene travels to the extrahepatic organs through the systemic blood and is available there for its biological action. Lycopene and cardiovascular diseases: an update. Gac has high lycopene content derived mainly from its seed coats. 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